Last night I got a thousand words down on my second novel in progress. I've about decided that I'm going to experiment with self e-publishing with this piece, because it's not the main genre I want to write in, so if it goes badly, then hopefully I won't screw up my chances at traditional publishing.
A lot of literary agents / editors / publishers are blogging about the changing publishing environment, and the possibility that someday soon, all books will be e-books. I don't believe this will be the case, (though in fairness, I am about two steps from a Luddite and hate reading books electronically, so my opinion could be catastrophically wrong.)
I think e-books are here to stay, and that they will be extremely popular in the future. However, they are a different enough format from traditional tree-flavor books that I don't think they are in a Highlander situation here. When movies and television started up, people stated that it would be an end to reading. Who would spend 3 hours reading a 300 page book on WWII when there was a snazzy movie with hot-bodied celebs to display pertinent information in a handy 150 minutes? As it turns out, a lot of people. The people who were prone to watching the movies instead of reading the book were, in a lot of cases, not the sort of people who were going to read the book anyways.
However, I think e-publishing in certain genres will be the way to go. Young Adult of course, and the cheap romance / fantasy / sci-fi novels. Those genres are full of people buying in bulk and volume, without expecting much in the way of emotional depth or re-readability. (As an aside, I like all four of those categories, but I rarely buy any books in them, because I buy those books I would want to re-read. Urges to read those categories are satisfied by my library card.)
I don't think mystery fiction will go that route as wholeheartedly, because mystery-lovers strike me as traditional readers. They find something they like, and stick with it. They're also typically looking for a little more from their books than a cheap thrill. They want to be intellectually stimulated, and it's rare to see sloppily-written mystery fiction churned out with the same frequency as the other categories mentioned above.
We'll see, I suppose. In the meantime, back to writing.